Accutane can cause major skin dryness and irritation, and in some patients that dryness leads to an eczema-like rash, often called retinoid dermatitis, especially on the hands, arms, and other exposed areas. Accutane and eczema are linked mainly through barrier damage: isotretinoin lowers oil production, makes skin more sensitive, and can leave it dry, itchy, and inflamed, and more easily triggered by soap, friction, weather, or sun exposure.
In most cases, the first steps are gentle skin care, a thick moisturizer or ointment, regular lip balm, and cutting back on products or habits that worsen dryness, such as exfoliants, harsh cleansers, and excessive sun exposure.