Opzelura

Use Opzelura® (ruxolitinib cream) as prescribed to help treat eczema (atopic dermatitis) by targeting inflammatory pathways in the skin that drive itching, redness, and irritation—without the use of topical steroids.

Customized prescription treatments for eczema within 24 hours
Prescriptions sent to your pharmacy (*often covered by insurance)
Convenient fast treatments 100% online

What is Opzelura, and how does it treat eczema?

Opzelura is a topical Janus kinase (JAK) inhibitor that targets inflammation at the cellular level. It reduces redness, itching, and lesions in mild to moderate eczema.

Who is a good candidate for Opzelura?

It is prescribed for individuals with mild to moderate eczema who have not responded well to topical steroids or other treatments.

How long does it take for Opzelura to work?

Improvement is often seen within 1–2 weeks, with continued improvement over several months of use.

Opzelura is prescribed for adults and adolescents with mild to moderate eczema who are not adequately controlled with topical therapies or when topical steroids are not suitable. It may be used on sensitive areas, including the face and skin folds, under clinician guidance. See pricing details here.

Real patients, real results

“Very happy to have been able to clear my skin conveniently from home.”

Samuel

DermOnDemand patient

“My cystic acne had been bothering me for a while, but now it's gone so thank you!”

Katie

DermOnDemand patient

“Acne annoyed me much of my life because of the constant visits to the dermatologist, now I can be treated from home.”

Talia

DermOnDemand patient

“DermOnDemand thank for making this possible to get great care for my acne without having to take off from work.”

Holly

DermOnDemand patient

“Feeling blessed with my clear skin that I finally achieved.”

Riley

DermOnDemand patient

How effective is Opzelura

Clinically proven results

Rapid itch relief and clearer skin with significant improvement in eczema symptoms.*

Clinical studies show that Opzelura can reduce itching as early as Day 2, with continued improvement in redness, inflammation, and overall skin appearance over time.

*In clinical trials, many patients using Opzelura achieved clear or almost clear skin and meaningful itch reduction within 8 weeks compared to placebo.

Opzelura should be used only as prescribed. For more details, see Important Safety Information.

How DermOnDemand Works

01

Answer questions & submit photos

Quickly share your skin concerns by answering a few questions and uploading photos—it takes just 5 minutes.

02

Quick expert evaluation

Our dermatology team will carefully review your information, diagnose your condition, and create a tailored plan within 24 hours.

03

Personalized treatment

Your customized plan will be sent directly to you, and prescriptions (if needed) will go straight to your pharmacy.

Common Question

What are the side effects of Opzelura?

Common side effects include mild redness or irritation at the application site. Rarely, it may affect immune function with prolonged use.

Can Opzelura be used long-term?

Yes, Opzelura can be used long-term under the guidance of your doctor for chronic eczema management.