Tacrolimus and Pimecrolimus

Use Tacrolimus and Pimecrolimus (topical calcineurin inhibitors) as prescribed to help treat eczema (atopic dermatitis) by calming immune-related skin inflammation without the use of topical steroids.

Customized prescription treatments for eczema within 24 hours
Prescriptions sent to your pharmacy (*often covered by insurance)
Convenient fast treatments 100% online

What are Tacrolimus and Pimecrolimus, and how do they treat eczema?

Tacrolimus and Pimecrolimus are non-steroidal topical medications (calcineurin inhibitors) that reduce inflammation by suppressing immune responses in the skin. They are particularly effective for sensitive areas like the face, neck, and folds.

Who should use Tacrolimus or Pimecrolimus?

These medications are suitable for individuals with mild to moderate eczema, especially those who need long-term treatment or cannot tolerate steroids.

How long does it take to see results with Tacrolimus or Pimecrolimus?

Improvement is usually seen within 1–2 weeks of consistent use, with ongoing improvement over several months.

Tacrolimus and Pimecrolimus are prescribed for adults and children with mild to moderate eczema, particularly in sensitive areas such as the face, eyelids, neck, and skin folds. They may be used when topical steroids are not suitable or for long-term maintenance under clinician guidance. See pricing details here.

Real patients, real results

“The itching and redness have reduced significantly — such a relief.”

Meaghan

DermOnDemand patient

"My amazing results after just two weeks of using Grahams Natural. Now I'm flare up free."

Ricki

DermOnDemand patient

“My skin looks healthier, and flare-ups are much less frequent now.”

Tamara

DermOnDemand patient

"Within just a few days I started to notice the difference, and within a few weeks it was gone."

Billy

DermOnDemand patient

“My skin feels calmer, smoother, and far less irritated than before.”

Katie

DermOnDemand patient

Clinically proven results

Significant improvement in eczema symptoms

including reduced redness, itching, and inflammation with consistent use.*

Clinical studies show that Tacrolimus and Pimecrolimus effectively control eczema flare-ups, helping restore the skin barrier and reduce the need for topical steroids when used as part of a long-term treatment plan.

*In clinical studies, patients using topical calcineurin inhibitors experienced noticeable improvement in eczema severity within 1–3 weeks compared to placebo.

Tacrolimus and Pimecrolimus should be used only as prescribed. For more details, see Important Safety Information.

How DermOnDemand Works

01

Answer questions & submit photos

Quickly share your skin concerns by answering a few questions and uploading photos—it takes just 5 minutes.

02

Quick expert evaluation

Our dermatology team will carefully review your information, diagnose your condition, and create a tailored plan within 24 hours.

03

Personalized treatment

Your customized plan will be sent directly to you, and prescriptions (if needed) will go straight to your pharmacy.

Common Question

What are the side effects of Tacrolimus and Pimecrolimus?

Common side effects include a mild burning or stinging sensation at the application site, which typically resolves after the first few days of use.

Are Tacrolimus and Pimecrolimus safe for long-term use?

Yes, these medications are safe for long-term use under medical supervision and do not cause skin thinning like steroids.

Can Tacrolimus and Pimecrolimus be combined with other treatments?

Yes, they are often combined with moisturizers and other treatments to enhance eczema management.