Yes, Accutane can cause fatigue in some patients, although it does not affect everyone. Studies suggest this side effect occurs in a minority of users, often linked to the body adjusting to the medication and to related symptoms such as muscle pain, dry eyes, or changes in sleep.
Fatigue during treatment is usually mild and temporary. It may result from combined effects on metabolism, the central nervous system, and physical symptoms like joint discomfort. In most cases, energy levels improve as the body adapts or after treatment ends, and persistent or severe fatigue is uncommon but should be evaluated.